precise GENOME engineering, no breaks
Genetic medicine is at a tipping point.
Next-generation genome editing.
RNA-based, damage-free, programmable and highly specific.
intelligently designed, programmable systems that enable safe, precise, and efficient genome engineering for all living organisms.
Gene Weaver is pioneering a new class of programmable, RNA-based genome engineering technologies designed to achieve precise, efficient, and safe genetic modification. Our carefully engineered molecular machines combine all steps of DNA recognition, strand joining, and DNA synthesis in a single, compact system. We will enable insertions of several kilobase’s of genetic cargo without introducing double-strand breaks or unintended genomic damage.
today’s GENE editing tools
HAVE LIMITATIONS
Applications. Rewriting how genes are delivered and expressed: from discovery to therapy.
INDUSTRIAL APPLICAITONS
Engineering industrial microbes or plants for improved yields and performance.
Gene Weaver’s gene insertion platform will enable insertion of gene cassettes or inactivation of endogenous genes without relying on double strand breaks. The high efficiency of our system makes it ideal for difficult to engineer microbes to be modified for applied industrial applications.
Genetic Medicine
Precise manipulation of DNA and RNA to modify gene function and repair of mutations.
By supporting large and complex genetic constructs and maintaining high editing efficiency in traditionally hard-to-engineer cells (including primary immune and stem cells), Gene Weaver will extend the reach for next-generation gene and cell therapies, including mitochondrial genome engineering, beyond the scope of existing technologies.
Components of our system may also be utilised to generate perfect RNA circles (cRNA) in vivo offering an enhanced system for gene expression via the persistence of circular RNA, offering improved therapeutic potential for mRNA vaccines or in vivo CAR-T cell therapies.
ENGINEERING GENE DRIVes
Unique potential for non-CrispR gene drive engineering
Our platform is derived from natural microbial gene drive elements. Appropriately designed the Gene Weaver elements can be configured to act as efficient gene drives in diverse applications including elimination of mitochondrial genome heteroplasmy, control of invasive species, and novel antimicrobial therapies.
We’d love to hear from you.
Whether you’re interested in learning more about our programmable gene integration technology, exploring collaboration opportunities, or just want to connect with the team, we’d be delighted to have a conversation. Fill out the form here and a member of the Gene Weaver team will get back to you as soon as possible.
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