precise GENOME engineering, no breaks
Genetic medicine is at a tipping point.
Next-generation genome editing.
RNA-based, damage-free, programmable and highly specific.
intelligently designed, programmable systems that enable safe, precise, and efficient genome engineering for all living organisms.
Gene Weaver is pioneering a new class of programmable, RNA-based genome engineering technologies designed to achieve precise, efficient, and safe genetic modification. Our carefully engineered molecular machines combine all steps of DNA recognition, strand joining, and DNA synthesis in a single, compact system. We will enable insertions of several kilobases of genetic cargo without introducing double-strand breaks or unintended genomic damage.
today’s GENE editing tools
HAVE LIMITATIONS
Limited Target Flexibility
Most genome editing tools (like CRISPR or TALENs) are constrained by strict sequence requirements, limiting where edits can be made.
Gene Weaver's Solution:
Our highly programmable system can target virtually any genomic site, using AI-guided design to evolve precision at scale.
Inefficient Large-Scale Gene Insertion
Current methods struggle with inserting long DNA sequences in many cells, restricting the ability to correct mutations with gene casettes.
Gene Weaver's Solution:
Our technology enables kilobase-scale integrations, supporting efficient repair of almost any genetic defect and enabling sophisticated engineering of plants and animals.
DNA DAMAGE FROM DOUBLE-STRAND BREAKS
Double-strand breaks (DSBs) often lead to unwanted mutations and genomic instability.
Gene Weaver's Solution:
Our no-break, RNA-based approach integrates genes safely without introducing DSBs - dramatically reducing off-target damage and improving cell viability.
Fragmented, Multi-Component Editing Systems
Many gene-editing tools rely on loosely assembled components with limited regulation or coordination.
Gene Weaver's Solution:
We engineer single, integral molecular machines that perform all steps — from DNA recognition to synthesis — within one precisely controlled system.
Applications. Rewriting how genes are delivered and expressed: from discovery to therapy.
INDUSTRIAL APPLICATiONS
Engineering industrial microbes or plants for improved yields and performance.
Gene Weaver’s gene insertion platform will enable insertion of gene cassettes or inactivation of endogenous genes without relying on double-strand breaks. The high efficiency of our system makes it ideal for difficult to engineer microbes to be modified for applied industrial applications.
Genetic Medicine
Precise manipulation of DNA and RNA to modify gene function and repair mutations.
By supporting large and complex genetic constructs and maintaining high editing efficiency in traditionally hard-to-engineer cells (including primary immune and stem cells), Gene Weaver will extend the reach for next-generation gene and cell therapies, including mitochondrial genome engineering, beyond the scope of existing technologies.
Components of our system may also be utilised to generate perfect RNA circles (cRNA) in vivo, offering an enhanced system for gene expression via the persistence of circular RNA, offering improved therapeutic potential for mRNA vaccines or in vivo CAR-T cell therapies.
ENGINEERING GENE DRIVes
Unique potential for non-CRISPR gene drive engineering.
Our platform is derived from natural microbial gene drive elements. Appropriately designed, the Gene Weaver elements can be configured to act as efficient gene drives in diverse applications, including elimination of mitochondrial genome heteroplasmy, control of invasive species, and novel antimicrobial therapies.
We’d love to hear from you.
Whether you’re interested in learning more about our programmable gene integration technology, exploring collaboration opportunities, or just want to connect with the team, we’d be delighted to have a conversation. Fill out the form here and a member of the Gene Weaver team will get back to you as soon as possible.
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